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Gene polymorphism and plasma levels of miR-155 in diabetic retinopathy

E R Polina1, F M Oliveira1, R C Sbruzzi1

  • 1Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil.

Endocrine Connections
|November 22, 2019
PubMed

Insights

The rs767649 polymorphism in the pre-MIR155 gene is linked to diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) patients. While miR-155 plasma levels may relate to T2DM, they were not associated with DR severity or the polymorphism.

Area of Science:

  • Genetics
  • Endocrinology
  • Ophthalmology

Background:

  • Circulating microRNA-155 (miR-155) is implicated in type 2 diabetes mellitus (T2DM).
  • The rs767649 polymorphism within the pre-MIR155 gene influences miR-155 expression.
  • The specific relationship between miR-155, its genetic variants, and diabetic retinopathy (DR) remains unclear.

Purpose of the Study:

  • To investigate the association between the rs767649 polymorphism in the pre-MIR155 gene and DR in South Brazilian T2DM patients.
  • To evaluate the correlation of plasma miR-155 levels with DR and the rs767649 polymorphism in a subset of T2DM patients.

Main Methods:

  • A case-control study genotyped the rs767649 polymorphism in 139 blood donors and 546 T2DM patients (categorized by DR presence and severity).
  • Plasma miR-155 expression was quantified in 20 blood donors and 60 T2DM patients.
  • Statistical analyses, including adjusted odds ratios, were used to assess associations.

Main Results:

  • The A allele of the rs767649 polymorphism was more frequent in T2DM patients with DR.
  • Carriership of the A allele and the A allele itself were independently associated with an increased risk of DR (adjusted OR = 2.12).
  • Plasma miR-155 levels were lower in T2DM patients than in blood donors but did not correlate with DR presence, severity, or rs767649 genotypes.

Conclusions:

  • The rs767649 polymorphism in the pre-MIR155 gene is associated with DR in T2DM patients.
  • Plasma miR-155 levels may be associated with T2DM itself.
  • Further research is warranted to elucidate the clinical significance of these findings in DR and T2DM.
Keywords:
diabetic retinopathygene expressionmiR-155plasmapolymorphismtype 2 diabetes

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