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    Area of Science:

    • Immunology
    • Hematology

    Background:

    • Common variable immune deficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia and impaired antibody production.
    • It affects adults, typically between 20-40 years old, with equal prevalence in males and females.

    Observation:

    • CVID diagnosis involves low serum IgG, IgA, and IgM levels with a lack of protective antibodies.
    • Hallmarks include sinopulmonary infections, but noninfectious autoimmune/inflammatory conditions like immune thrombocytopenia, hemolytic anemia, neutropenia, splenomegaly, lymphadenopathy, and lymphoma can also be presenting signs.

    Findings:

    • The article presents three cases of CVID where hematologic issues were the initial presentation.
    • It highlights the critical role of hematology in the evaluation and management of CVID patients with these hematologic manifestations.

    Implications:

    • Recognizing hematologic presentations in CVID is crucial for timely diagnosis and appropriate management.
    • This underscores the interdisciplinary approach needed for comprehensive CVID care, involving both immunologists and hematologists.