Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retina01:32

The Retina

73.9K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
73.9K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

9.2K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
9.2K
Vision01:24

Vision

59.1K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
59.1K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.4K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.4K
Unrenewable Cells00:50

Unrenewable Cells

2.7K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fixed-dose telmisartan/hydrochlorothiazide in comparison with losartan/hydrochlorothiazide in decreasing serum hepatocyte growth factor and improving endothelial dysfunction in hypertensive patients.

International heart journal·2010
Same author

[Relationship between Mutations of the Epidermal Growth Factor Receptor Gene and Drug-Resistance to Gefitinib in Human Lung Cancer in vitro.].

Zhongguo fei ai za zhi = Chinese journal of lung cancer·2010
Same author

Pupal diapause of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) mediated by larval host plants: pupal weight is important.

Journal of insect physiology·2010
Same author

Clinical application and evaluation of anti-TNF-alpha agents for the treatment of rheumatoid arthritis.

Acta pharmacologica Sinica·2010
Same author

Regulatory effect of melatonin on cytokine disturbances in the pristane-induced lupus mice.

Mediators of inflammation·2010
Same author

Management of maxillary sinus inverted papilloma via transnasal endoscopic anterior and medial maxillectomy.

ORL; journal for oto-rhino-laryngology and its related specialties·2010
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
Same journal

Microglial fitness in moderation: Tuning TREM2 signaling through Ptpn6.

Neuron·2026
See all related articles

Related Experiment Video

Updated: Dec 22, 2025

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
07:12

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

Published on: April 11, 2025

786

Decreasing Influence of Retinal Inputs on the Developing Visual Cortex.

Wei Wei1

  • 1Department of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, IL, USA.

Neuron
|November 22, 2019
PubMed
Summary
This summary is machine-generated.

Spontaneous retinal activity shapes developing visual pathways. Researchers imaged connected mouse visual areas, revealing distinct signal processing in thalamocortical and retinocollicular pathways during early development.

More Related Videos

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
06:16

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies

Published on: July 28, 2023

3.0K
Using Looming Visual Stimuli to Evaluate Mouse Vision
05:07

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

12.1K

Related Experiment Videos

Last Updated: Dec 22, 2025

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
07:12

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

Published on: April 11, 2025

786
Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
06:16

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies

Published on: July 28, 2023

3.0K
Using Looming Visual Stimuli to Evaluate Mouse Vision
05:07

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

12.1K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Visual System Research

Background:

  • Early visual system development relies on spontaneous retinal activity to shape neural circuits.
  • Understanding how this activity is processed in different downstream pathways is crucial for comprehending visual maturation.

Purpose of the Study:

  • To investigate the distinct developmental patterns of signal transformation in connected visual areas.
  • To compare the processing of spontaneous retinal activity in the thalamocortical and retinocollicular pathways.

Main Methods:

  • Simultaneous in vivo imaging of neural activity in connected mouse visual areas.
  • Analysis of signal dynamics and transformation across different developmental stages.

Main Results:

  • Distinct developmental trajectories were observed in the thalamocortical and retinocollicular pathways.
  • Signal processing and transformation exhibit unique patterns specific to each pathway during development.

Conclusions:

  • Spontaneous retinal activity undergoes differential processing in major visual pathways during development.
  • These findings highlight pathway-specific mechanisms shaping the developing visual system before mature vision is established.