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Updated: Jan 3, 2026

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
Published on: June 13, 2017
Cortex-wide Computations in Complex Decision Making in Mice
Pankaj K Gupta1, Timothy H Murphy1
1Department of Psychiatry, Kinsmen Laboratory of Neurological Research; University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Abstract:
Seemingly, a paradox exists between reports of wide-scale task-dependent cortical activity and the causal requirement for only a restricted number of motor and sensory cortical areas in some behavioral studies. In this issue of Neuron, Pinto et al. (2019) indicate that scenarios where mice must accumulate evidence and hold it during a delay period are causally linked to wide regions of cortex.
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