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The involvement of post-translational modifications in cardiovascular pathologies: Focus on SUMOylation, neddylation,

Jinning Gao¹, Kai Shao², Xiatian Chen¹

¹Center for Molecular Genetics, Institute for Translational Medicine, Faculty of Medicine, Qingdao University, Qingdao 266021, China.

Journal of Molecular and Cellular Cardiology

|November 22, 2019

Insights

Protein post-translational modifications (PTMs) are crucial in cardiovascular disease (CVD) progression. Aberrant PTMs offer potential therapeutic targets for treating CVDs by correcting abnormal protein functions.

Area of Science:

Biochemistry
Molecular Biology
Cardiology

Background:

Cardiovascular disease (CVD) poses a significant global health threat, with increasing prevalence.
The intricate intracellular mechanisms underlying CVD pathogenesis remain incompletely understood.
Protein post-translational modifications (PTMs) are dynamic regulators of protein function, distinct from static genetic mutations.

Purpose of the Study:

To review recent advancements in understanding PTMs in the context of cardiovascular diseases.
To highlight specific PTMs, including SUMOylation, neddylation, succinylation, and prenylation, and their roles in CVD.
To explore the potential of targeting aberrant PTMs for novel CVD therapeutics.

Main Methods:

Literature review of recent research on PTMs and cardiovascular disease.
Focus on specific PTMs: SUMOylation, neddylation, succinylation, and prenylation.
Analysis of how PTMs influence cardiovascular function and disease progression.

Main Results:

PTMs reversibly modulate protein activity, stability, localization, and interactions, acting as key mediators in CVD.
Pathological conditions lead to imbalanced PTMs, altering protein expression, localization, and signaling.
SUMOylation, neddylation, succinylation, and prenylation are identified as critical PTMs in cardiovascular health and disease.

Conclusions:

Aberrant PTMs play a significant role in the progression of cardiovascular diseases.
Correcting dysregulated PTMs presents a promising therapeutic strategy for CVD treatment.
Further research into specific PTMs may unveil novel targets for cardiovascular therapeutics.

Read full analysis

Abstract:

Cardiovascular disease (CVD) is one of the most threatening diseases to human health and life, and the number of patients is increasing year by year. Thus, it is of great significance to study the pathogenesis, prevention and treatment of CVDs. The occurrence and development of CVDs involve dynamic, complex and delicate intracellular processes and the pathogenesis is not entirely clear. In contrast to genetic mutations, most of the protein post-translational modifications (PTMs) are reversible, and can affect the activity, stability, subcellular localization, protein-protein interaction etc., of the substrate targets, emerging as key mediators of a number of CVD progression. Under pathological conditions, the PTMs undergo aberrant balances which cause changes of the substrate target proteins in expression level, localization and capacity to activate downstream signaling pathways. Therefore, new approaches can be created aiming to correct the abnormal PTM alterations in treating CVDs. This review summarizes some of the more recent advances in PTMs, focusing on SUMOylation, neddylation, succinylation, and prenylation, and the effect of these modifications on cardiovascular function and progression, which may provide potential targets for future therapeutics.

Keywords:

Cardiovascular disease Neddylation Post-translational modification Prenylation SUMOylation Succinylation

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