Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

1.1K
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
1.1K
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

197
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
197
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

532
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
532
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

160
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
160
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

141
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
141
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

651
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
651

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evoking nostalgia by presenting hit-song lists.

Frontiers in psychology·2026
Same author

TIGRIS and EUPHRATES eventually join and provide new evidence: a narrative review of the polymyxin B hemoperfusion.

Journal of intensive care·2025
Same author

Is Antithrombin Supplementation Effective in Suppressing ECMO Circuit Thrombosis in Sepsis?

Juntendo medical journal·2025
Same author

Endotoxin Activity Assay-Guided Patient Selection for Polymyxin B Hemoperfusion: Lessons from the TIGRIS Trial and Future Directions.

Healthcare (Basel, Switzerland)·2025
Same author

Granulomonocytapheresis for chronic inflammatory diseases and sepsis.

Journal of intensive care·2025
Same author

Impact of group dancing during Japanese festivals on people's sense of community.

Frontiers in psychology·2025

Related Experiment Video

Updated: Jan 3, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
11:23

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

972

Validity of Intermittent Infusion Hemodiafiltration.

Michio Mineshima1, Kei Eguchi2

  • 1Department of Clinical Engineering, Tokyo Women's Medical University, Tokyo, Japan, mmine@twmu.ac.jp.

Blood Purification
|November 22, 2019
PubMed
Summary

Intermittent infusion hemodiafiltration (I-HDF) improves plasma refilling rates and reduces the need for medical interventions during dialysis. This hemodialysis (HD) alternative offers a safer treatment option for patients by preventing blood pressure drops.

Keywords:
BackfiltrationIntermittent infusion hemodiafiltrationPeripheral circulationPlasma refilling

More Related Videos

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

924
A Murine Model of Hemodialysis Access-Related Hand Dysfunction
08:39

A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Published on: May 31, 2022

2.0K

Related Experiment Videos

Last Updated: Jan 3, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
11:23

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

972
Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

924
A Murine Model of Hemodialysis Access-Related Hand Dysfunction
08:39

A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Published on: May 31, 2022

2.0K

Area of Science:

  • Nephrology
  • Cardiovascular Physiology
  • Renal Replacement Therapy

Background:

  • Intermittent infusion hemodiafiltration (I-HDF) was developed to mitigate intradialytic hypotension and enhance peripheral circulation.
  • Over 10,000 dialysis patients in Japan utilized I-HDF in 2017, with increasing adoption.
  • I-HDF involves periodic infusion of dialysis fluid, functioning as a low-volume online hemodiafiltration (HDF).

Purpose of the Study:

  • To evaluate the efficacy of I-HDF compared to conventional hemodialysis (HD).
  • To assess I-HDF's impact on hemodynamic stability and patient outcomes.
  • To investigate I-HDF's effects on solute clearance and fluid balance.

Main Methods:

  • Clinical trials comparing I-HDF with HD were reviewed.
  • Hemodynamic parameters, including time-averaged blood volume and plasma refilling rate, were analyzed.
  • Incidence of medical interventions, solute levels (β2-microglobulin, α1-microglobulin), and albumin leak were assessed.

Main Results:

  • I-HDF demonstrated a significantly greater plasma refilling rate compared to HD.
  • A reduced incidence of events requiring medical intervention was observed with I-HDF.
  • I-HDF showed comparable or improved solute removal and reduced albumin leak compared to other HDF methods.

Conclusions:

  • I-HDF is a viable treatment option for dialysis patients.
  • I-HDF effectively increases plasma refilling rates, improving hemodynamic stability.
  • I-HDF reduces the frequency of interventions for intradialytic hypotension and tachycardia.