Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comprehensive CFD lifecycle dataset for marine vessel hydrodynamics.

Scientific data·2026
Same author

Isolation of ROMP-Generated Macrocyclic Polyalkenamers via Polar Monomer Incorporation and Chain-End Modification.

Macromolecules·2026
Same author

Real-world experience with efgartigimod in generalized myasthenia gravis: a single-center retrospective study in China.

Frontiers in immunology·2026
Same author

Construction of quaternary stereocenters via Ru-catalyzed asymmetric ring-closing metathesis.

Nature communications·2026
Same author

Causal Exposures of Immune Cells in Neuromyelitis Optica Spectrum Disorders: A Mendelian Randomization Study and Flow Cytometry Analysis.

Brain and behavior·2026
Same author

Rhodium-Catalyzed Desymmetric Addition of Boronic Acids to Malononitriles.

Journal of the American Chemical Society·2026

Related Experiment Video

Updated: Jan 3, 2026

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
10:55

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

14.3K

Engineering a Bi-Conical Microchip as Vascular Stenosis Model.

Yan Li1, Jianchun Wang1, Wei Wan1

  • 1Energy Research Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.

Micromachines
|November 23, 2019
PubMed
Summary
This summary is machine-generated.

Researchers created a novel blood-vessel-on-a-chip model using bi-conical hydrogel microchannels. This vascular stenosis model accurately mimics hemodynamic changes and cell behavior, aiding in thrombosis research.

Keywords:
bi-conicalblood-vessel-likemicrochipvascular stenosiswall shear rate

More Related Videos

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
06:12

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

537
Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall
11:47

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Published on: July 6, 2022

3.7K

Related Experiment Videos

Last Updated: Jan 3, 2026

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
10:55

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

14.3K
Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
06:12

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

537
Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall
11:47

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Published on: July 6, 2022

3.7K

Area of Science:

  • Biomaterials Engineering
  • Cardiovascular Research
  • Microfluidics

Background:

  • Vascular stenosis significantly alters blood flow dynamics, particularly affecting wall shear stress.
  • Understanding these hemodynamic changes is crucial for diagnosing and treating conditions like arterial thrombosis.

Purpose of the Study:

  • To develop a novel microfluidic device that accurately replicates vascular stenosis.
  • To investigate the impact of altered shear stress on endothelial cells within a controlled microenvironment.
  • To create a platform for evaluating blood hydrodynamics in stenosis models.

Main Methods:

  • Fabrication of bi-conical shaped hydrogel microvessels using templated methods.
  • Integration of human umbilical vein endothelial cells (HUVECs) to form blood-vessel-like lumens.
  • Simulation of wall shear rates in the narrowing regions using FLUENT software.

Main Results:

  • The developed microvessels exhibited tunable dimensions, perfusability, and cytocompatibility.
  • HUVECs successfully lined the microchannels, mimicking native blood vessel morphology and function.
  • Simulations confirmed that the microchannels generate relevant wall shear stress patterns characteristic of stenosis.
  • Observed cell morphology variations correlated with altered shear stress in the narrowing regions.

Conclusions:

  • The bi-conical microfluidic chip serves as a viable vascular stenosis model for studying blood hydrodynamics.
  • This blood-vessel-on-a-chip platform offers potential for advancing the prevention, diagnosis, and therapy of arterial thrombosis.