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Retrovirus Life Cycles01:10

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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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A User's Guide to the Inverted Terminal Repeats of Adeno-Associated Virus.

Patrick Wilmott1, Leszek Lisowski1,2,3, Ian E Alexander4,5

  • 1Translational Vectorology Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.

Human Gene Therapy Methods
|November 23, 2019
PubMed
Summary

Adeno-associated virus (AAV) vectors are crucial for gene transfer and editing. This review focuses on the complex inverted terminal repeats (ITRs), offering guidance for users and developers of AAV vector technology.

Failed At:

2026-06-19T13:38:25.971079+00:00

Keywords:
AAVITRadeno-associated virusinverted terminal repeatsquality control

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