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Stinging Insect Allergens.

Le Cui1, Ying-Yang Xu1, Xiu-Jie Wang2

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Current Protein & Peptide Science
|November 23, 2019
PubMed
Summary

Hymenoptera venom allergy diagnosis can be improved with component-resolved diagnosis, identifying specific allergic reactions to proteins. This method aids in predicting the effectiveness and safety of venom immunotherapy.

Keywords:
AllergensHymenopteracross-reactionshypersensitivityimmunoglobulin Eimmunotherapyvenoms.

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Area of Science:

  • Immunology
  • Allergology
  • Entomology

Background:

  • Hymenoptera venom allergy is a frequent cause of anaphylaxis.
  • Diagnosis often shows inconsistency between patient history and venom-specific IgE levels.

Purpose of the Study:

  • To review studies on Hymenoptera venom allergens, component-resolved diagnosis, and its predictive value for venom immunotherapy.
  • To examine the prevalence of Hymenoptera venom allergy in Asian countries.

Main Methods:

  • Review of scientific literature on WHO/IUIS-accepted Hymenoptera venom allergens.
  • Analysis of studies utilizing component-resolved diagnosis for Hymenoptera venom allergy.
  • Evaluation of predictive values of component-resolved diagnosis for venom immunotherapy outcomes.

Main Results:

  • Component-resolved diagnosis allows precise localization of allergic reactions to specific venom proteins.
  • This approach enhances the understanding of allergenicity and cross-reactivity.
  • Data on the spread of Hymenoptera venom allergy in Asia was considered.

Conclusions:

  • Component-resolved diagnosis offers a more accurate method for diagnosing Hymenoptera venom allergy.
  • It improves the prediction of venom immunotherapy efficacy and safety.
  • Further research into regional variations, especially in Asia, is warranted.