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Updated: Jan 3, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
16.4K
Pathology of Melanoma
Asmita Chopra1, Rohit Sharma2, Uma N M Rao3
1Department of Surgery, Division of Surgical Oncology, University of Pittsburgh, Room A-422, Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
The Surgical Clinics of North America
|November 23, 2019
Summary
This review covers melanoma pathology, from basic features to advanced diagnostics like immunohistochemistry and genetic sequencing. Key prognostic factors, including invasion depth and metastasis, remain crucial for patient outcomes.
Area of Science:
- Dermatopathology
- Oncology
- Molecular Pathology
Background:
- Melanoma is an aggressive skin cancer originating from melanocytes.
- Pathological understanding has advanced from morphology to molecular techniques.
- Extracutaneous melanoma is rare but recognized.
Purpose of the Study:
- To review the evolving pathology of melanoma.
- To highlight key prognostic indicators in melanoma.
- To discuss recent advancements in melanoma diagnosis.
Main Methods:
- Review of existing literature on melanoma pathology.
- Analysis of traditional histopathological features.
- Integration of immunohistochemistry and genetic sequencing findings.
Main Results:
- Depth of invasion and lymph node metastasis are primary prognostic factors.
- Ulceration, lymphovascular invasion, mitosis, and tumor-infiltrating lymphocytes are also significant.
- Modern diagnostics enhance melanoma classification and understanding.
Conclusions:
- Pathology of melanoma has significantly evolved.
- Accurate diagnosis relies on integrating clinical, histological, and molecular data.
- Prognostic feature assessment remains critical for melanoma management.
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