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Neuroimaging in aging and neurologic diseases
Shannon L Risacher1, Andrew J Saykin1
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States.
Handbook of Clinical Neurology
|November 23, 2019
Summary
Neuroimaging, including MRI and PET scans, aids in understanding brain diseases and diagnosing conditions like Alzheimer's and other dementias. These techniques are crucial for differentiating between various neurologic disorders.
Area of Science:
- Neurology
- Radiology
- Neuroscience
Background:
- Neuroimaging biomarkers are essential for understanding the pathology of neurologic diseases.
- These biomarkers aid in diagnosing cognitive and clinical symptoms and in differential diagnosis.
Purpose of the Study:
- To explore various neuroimaging measures used in healthy aging and neurologic diseases.
- To cover a spectrum of neuroimaging findings from normal aging to diverse dementia types.
Main Methods:
- Utilizes structural and functional magnetic resonance imaging (MRI) measures.
- Incorporates molecular measures, primarily from positron emission tomography (PET).
Main Results:
- Details neuroimaging in healthy aging, Alzheimer's disease (AD), mild cognitive impairment (MCI), and various dementias.
- Discusses neuroimaging for frontotemporal dementia (FTD) subtypes, Parkinson's disease (PD), and other neurodegenerative disorders.
Conclusions:
- Highlights the role of neuroimaging in differential diagnosis of neurologic dementia disorders.
- Includes discussion on appropriate use criteria for amyloid imaging.
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