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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Association Areas of the Cortex01:21

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Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Prosopagnosia01:24

Prosopagnosia

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Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
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Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

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The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
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Related Experiment Video

Updated: Jan 3, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Frontotemporal dementia.

Emma M Devenney1, Rebekah M Ahmed2, John R Hodges1

  • 1Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.

Handbook of Clinical Neurology
|November 23, 2019
PubMed
Summary
This summary is machine-generated.

Frontotemporal dementia (FTD) is a common cause of early-onset dementia. Recent advances in genetics, neuroimaging, and biomarkers are improving our understanding of FTD and related disorders.

Keywords:
Behavioral variant frontotemporal dementiaBiomarkersC9orf72Frontotemporal lobar degenerationMotor neuron diseaseNeuroimagingPharmacologic therapyPrimary progressive aphasia

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Area of Science:

  • Neurology
  • Neuroscience
  • Genetics

Background:

  • Frontotemporal dementia (FTD) is the second leading cause of dementia in younger individuals.
  • Significant progress has been made in understanding FTD and related syndromes.
  • Key areas of advancement include the clinicopathologic and genetic overlap between FTD, motor neuron disease (MND), and other neurodegenerative conditions.

Purpose of the Study:

  • To discuss the clinical, pathologic, and genetic complexities of FTD and related disorders.
  • To highlight recent advancements in the field.
  • To provide a comprehensive overview for researchers and clinicians.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of clinicopathologic and genetic data.
  • Synthesis of information from neuroimaging and biomarker studies.

Main Results:

  • Significant overlap identified between FTD, MND, and other neurodegenerative diseases.
  • Advances in neuroimaging techniques offer new insights into FTD.
  • Discovery of novel genetic mutations and potential biomarkers is expanding knowledge.

Conclusions:

  • Continued research into the biologic processes of FTD is crucial.
  • Understanding the complexities of FTD and related disorders may lead to new therapeutic strategies.
  • Pharmacologic therapies for curative and preventative measures are a key future direction.