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Related Concept Videos

Dementia01:30

Dementia

469
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Jan 3, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

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Gait and dementia.

Jason A Cohen1, Joe Verghese2

  • 1Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States.

Handbook of Clinical Neurology
|November 23, 2019
PubMed
Summary
This summary is machine-generated.

Changes in gait, such as slower speed and increased variability, are linked to cognitive decline and neurodegenerative diseases. These gait changes can predict dementia and guide interventions for better patient care.

Keywords:
Clinical assessmentCognitionDementiaEpidemiologyFallsGaitMotoric cognitive risk syndrome

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Area of Science:

  • Neuroscience
  • Gerontology
  • Neurology

Background:

  • Cognitive decline and neurodegenerative diseases disrupt brain mechanisms controlling movement.
  • Gait dysfunction, including decreased velocity and increased variability, is a common symptom.

Purpose of the Study:

  • To explore the relationship between gait changes and cognitive decline.
  • To highlight gait as a potential biomarker for neurodegenerative diseases.
  • To discuss interventions for gait problems in dementia.

Main Methods:

  • Review of literature on gait and cognitive function.
  • Analysis of gait parameters (velocity, variability, multitasking) in relation to cognitive status.
  • Examination of clinical biomarkers like Motoric Cognitive Risk syndrome.

Main Results:

  • Cognitive decline correlates with impaired gait velocity, increased variability, and reduced multitasking ability.
  • Gait changes can predict mild cognitive impairment and dementia.
  • Motoric Cognitive Risk syndrome serves as a biomarker for neurological decline.

Conclusions:

  • Gait dysfunction is a significant indicator of cognitive impairment and neurodegenerative disease.
  • Interventions including physical and cognitive rehabilitation can improve gait.
  • Understanding the gait-dementia link is crucial for diagnosis and patient care.