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Nano formulated proanthocyanidins as an effective wound healing component
Rajendran Rajakumari1, Tatiana Volova2, Oluwatobi Samuel Oluwafemi3
1International and Inter-University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kerala 686560, India; Siberian Federal University, 79 Svobodnyi Av., Krasnoyarsk 660041, Russia.
Grape seed extract (GSE) proanthocyanidins (PCs) were developed into a nanoformulation (PCs/SOLU) for improved wound healing. This novel nanoformulation demonstrated significant antibacterial and anti-inflammatory effects, promoting faster wound contraction in rats.
Area of Science:
- Pharmacology and Pharmaceutics
- Biomaterials Science
- Wound Healing Research
Background:
- Proanthocyanidins (PCs) from grape seed extract (GSE) show therapeutic potential for wound treatment.
- Limitations of native PCs include poor absorption, stability, and rapid systemic elimination.
- Development of advanced delivery systems is crucial to overcome these limitations.
Purpose of the Study:
- To develop novel proanthocyanidin-based nanoformulations (PCs/SOLU) using 1% GSE.
- To evaluate the in-vivo wound healing efficacy of the developed PCs/SOLU nanoformulation.
- To assess the antibacterial and anti-inflammatory properties of PCs/SOLU.
Main Methods:
- PCs/SOLU nanodispersions were prepared from 1% GSE and incorporated into an ointment base.
- Antibacterial activity was tested against Gram-positive and Gram-negative bacteria.
- In-vivo wound healing was assessed on Wistar rats using excision wound models, with controls including GSE ointment and povidone-iodine.
Main Results:
- PCs/SOLU exhibited significant antibacterial activity, disrupting bacterial cell membranes.
- No inflammatory signs were observed in rat paw edema tests with PCs/SOLU.
- PCs/SOLU significantly improved wound contraction, enhanced cell adhesion and proliferation, and reduced inflammation.
Conclusions:
- PCs/SOLU nanoformulation effectively enhances wound healing by promoting fibroblast activity and inhibiting inflammatory responses.
- The developed nanoformulation overcomes the bioavailability challenges of native PCs.
- PCs/SOLU represents a promising topical treatment for accelerating wound repair.
