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Updated: Jan 3, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
New inductive proximity sensor platform for precise localization of small colorectal tumors
Vasile Bințințan1, Adrian Calborean2, Mihaela Mocan3
1Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, V. Babeş Street No. 8, 400012 Cluj-Napoca, Romania.
This study introduces an innovative inductive proximity switch system for precise intraoperative localization of gastrointestinal tumors during laparoscopic surgery. The developed electromagnetic probe and metallic tags offer improved tumor detection, enhancing surgical accuracy.
Area of Science:
- Biomedical Engineering
- Surgical Technology
- Medical Devices
Background:
- Intraoperative localization of small gastric or colorectal tumors during laparoscopic surgery presents challenges due to imprecise methods.
- A need exists for a compatible and straightforward tool to aid surgeons in precise tumor localization during procedures.
Purpose of the Study:
- To fabricate and evaluate a novel inductive proximity switch architecture for precise intraoperative localization of bowel tumors during laparoscopic surgery.
- To develop an electromagnetic detection probe and metallic markers suitable for laparoscopic use and sterilization.
Main Methods:
- Designed and constructed an electromagnetic detection probe optimized for laparoscopic surgery.
- Utilized various metallic markers (haemostatic clips, custom tags) attached to gastrointestinal mucosa for detection.
- Conducted experiments in dry-lab and wet-lab environments using ex-vivo animal and human surgical specimens.
Main Results:
- Detection range varied by metallic tag composition, from 0.5 mm (hemostatic clip) to 3.5 mm (custom stainless-steel tags).
- Custom tags were detectable through the serosal side of human colonic specimens in 85% of attempts under specific conditions (area < 150 cm², fat < 2 mm).
Conclusions:
- The newly designed system demonstrates potential for discovering metallic tags on bowel mucosa for precise intraoperative laparoscopic localization of digestive tumors.
- Further research is ongoing to enhance system sensitivity and detection range for clinical compatibility.
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