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The plasma supply in Germany.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis

|November 23, 2019

Summary

This summary is machine-generated.

Germany

Keywords:

Coagulation factors Immunoglobulin Plasma for fractionation Plasma supply Therapeutic plasma

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Area of Science:

Medical Sciences
Public Health
Biotechnology

Background:

Germany aims for self-sufficiency in plasma supply.
Previous efforts have been made to meet this demand.
This report details the current state of plasma supply in Germany.

Purpose of the Study:

To analyze the current status of plasma collection and utilization in Germany.
To assess trends in therapeutic plasma and source plasma for fractionation.
To evaluate the supply chain of plasma derivatives.

Main Methods:

Data collection from the Paul-Ehrlich-Institute.
Analysis of data on blood and plasma collection and use.
Review of import/export data for plasma derivatives.

Main Results:

Therapeutic plasma collection declined slightly but peaked in 2017.
Plasma for fractionation remained stable at approximately 2 million liters annually.
Immunoglobulin manufacturing increased, while Factor VIII and IX use persists.
Import/export activities ensure plasma derivative availability.
Fibrinogen supplementation and patient blood management reduced therapeutic plasma use.

Conclusions:

Germany's plasma supply chain is complex, involving domestic collection and international trade.
Increased immunoglobulin production addresses rising demand for treating immunodeficiencies.
Despite recombinant alternatives, plasma-derived Factor VIII and IX remain relevant.
Optimized clinical practices can reduce therapeutic plasma consumption.