Complete Genome Sequence of Proteus mirabilis Phage Mydo

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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
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Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

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Benjamin T Jones1, Lauren Lessor1, Chandler O'Leary1

  • 1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.

Microbiology Resource Announcements
|November 23, 2019
PubMed

Insights

A novel myophage, Mydo, was sequenced to explore potential therapeutics against antibiotic-resistant Proteus mirabilis infections. This research advances phage therapy options for challenging bacterial pathogens.

Area of Science:

  • Microbiology
  • Virology
  • Genomics

Background:

  • Proteus mirabilis is a significant cause of hospital-acquired infections.
  • Antibiotic resistance in P. mirabilis necessitates alternative treatment strategies.
  • Bacteriophages (phages) offer a promising avenue for combating resistant bacterial strains.

Purpose of the Study:

  • To announce the complete genome sequence of a P. mirabilis-infecting myophage, named Mydo.
  • To characterize Mydo and its relationship to other known phages.
  • To lay the groundwork for developing phage-based therapies against P. mirabilis.

Main Methods:

  • Whole-genome sequencing of the Mydo myophage.
  • Bioinformatic analysis of the Mydo genome.
  • Comparative genomics with related bacteriophages.

Main Results:

  • The complete genome sequence of the P. mirabilis myophage Mydo has been determined.
  • Mydo exhibits distant genetic relatedness to Escherichia coli phage rv5.
  • Genomic data provides a foundation for understanding Mydo's biological properties.

Conclusions:

  • The Mydo genome sequence provides valuable data for phage therapy development.
  • Understanding phage-host interactions is crucial for combating P. mirabilis infections.
  • Further research into Mydo may yield effective treatments for resistant P. mirabilis.

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