Related Experiment Video
Updated: Aug 11, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Effects of bile acids, antacids, and cholestyramine on transmural electrical potential difference in man
Abstract:
The effect of glycocholic acid (GCA) on functional changes of the gastric mucosal barrier was examined by measurement of transmural gastric potential difference (PD) in humans in the presence and absence of cholestyramine and of A1(OH)3-containing antacids possessing potent bile acid binding properties. Intagastric instillation of GCA induced reduction of PD which could be prevented by the more potent buffering Mg-A1(OH)3-containing antacid, but not by cholestyramine or the less potent A1(OH)3-containing antacid. It is concluded that for the prevention of bile acid induced damage of gastric mucosa potent antacids are superior to potent bile acid binding agents loosing the binding properties at low pH-values.
More Related Videos
Related Concept Videos
Depolarizing Blockers: Pharmocokinetics
Electrochemical Systems
Junction Potentials in Galvanic Cells
The Electrical Double Layer
Processes at Electrodes

