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Updated: Jan 3, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Strain Elastography-Targeted Biopsy: Does Prostate Volume Affect Prostate Cancer Detection?

Yi-Cheng Zhu1, Jun Shan1, Yuan Zhang1

  • 1Department of Ultrasound, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Pudong, Shanghai, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|November 23, 2019
PubMed
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This summary is machine-generated.

Strain elastography (SE)-guided targeted biopsy (TB) detects more prostate cancer (PCa) than conventional transrectal ultrasound (TRUS)-guided systematic biopsy (SB). SE-guided TB is particularly effective for smaller prostates, showing a negative correlation between prostate volume and detection rates.

Area of Science:

  • Urology
  • Medical Imaging
  • Oncology

Background:

  • Prostate cancer (PCa) diagnosis relies on biopsies.
  • Conventional transrectal ultrasound (TRUS)-guided systematic biopsy (SB) has limitations in detection.
  • Strain elastography (SE)-guided targeted biopsy (TB) offers a potential improvement.

Purpose of the Study:

  • To compare the detection rates of SE-guided TB versus TRUS-guided SB for PCa.
  • To investigate the correlation between prostate volume and PCa detection using SE-guided TB.

Main Methods:

  • Retrospective study of 357 patients with suspected PCa.
  • All patients underwent both TRUS-guided SB and SE-guided TB.
  • Pathological analysis of biopsy results determined PCa confirmation.

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Main Results:

  • PCa confirmed in 151/357 patients.
  • SE-guided TB increased PCa detection by 6.6% over TRUS-guided SB.
  • SE-guided TB sensitivity decreased with increasing prostate volume (p=0.002), showing higher efficacy in smaller glands (<30 ml).

Conclusions:

  • SE-guided TB demonstrates a higher PCa detection rate compared to TRUS-guided SB.
  • A negative correlation exists between prostate volume and SE-guided TB detection.
  • SE-guided TB can complement conventional SB, especially in patients with smaller prostates.