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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: Jan 3, 2026

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

Current Progress in CAR-T Cell Therapy for Solid Tumors.

Shuo Ma¹, Xinchun Li¹, Xinyue Wang¹

¹Shanghai Baize Medical Laboratory, Shanghai, China.

International Journal of Biological Sciences

|November 23, 2019

Summary

This summary is machine-generated.

Chimeric antigen receptor (CAR)-T cell therapy shows promise for blood cancers but faces challenges in solid tumors. This review explores CAR-T techniques, obstacles, and strategies for solid tumor treatment.

Keywords:

CAR-T cells CTC chimeric antigen receptor companion diagnostics solid tumors

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Area of Science:

Immunology and Oncology
Cellular Therapy

Background:

Chimeric antigen receptor (CAR)-T cell therapy has demonstrated significant clinical success in treating hematological malignancies.
Approved CAR-T therapies like Kymriah and Yescarta are utilized for B cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma, respectively.

Purpose of the Study:

To review the current status and trends in developing CAR-T cell-based therapies for solid tumors.
To highlight challenges and strategies for applying CAR-T cell therapy in solid tumor treatment.

Main Methods:

Review of existing literature on CAR-T cell techniques for solid tumors.
Analysis of obstacles hindering CAR-T cell efficacy in the tumor microenvironment.
Exploration of strategies and companion diagnostics for solid tumor CAR-T therapy.

Main Results:

CAR-T cell therapy faces significant hurdles in treating solid tumors, primarily due to the tumor microenvironment.
Research is focused on enhancing CAR-T cells and mitigating unfavorable tumor microenvironment effects.
Development of effective companion diagnostics is crucial for successful solid tumor treatment.

Conclusions:

While effective for blood cancers, CAR-T cell therapy requires further innovation for solid tumor application.
Overcoming tumor microenvironment challenges and implementing companion diagnostics are key for advancing CAR-T therapy in solid tumors.