Related Experiment Videos
AA amyloidosis associated with systemic lupus erythematosus
E J ter Borg1, S Janssen, M H van Rijswijk
1Department of Internal Medicine, University Hospital, Groningen, The Netherlands.
Rheumatology International
|January 1, 1988
Summary
Systemic lupus erythematosus rarely co-occurs with AA amyloidosis. A patient presented with kidney dysfunction and nephrotic syndrome, revealing amyloid deposits without lupus nephritis features.
Area of Science:
- Nephrology
- Rheumatology
- Pathology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- AA amyloidosis is a form of secondary amyloidosis associated with chronic inflammation.
- The co-occurrence of SLE and AA amyloidosis is uncommon.
Observation:
- A 54-year-old female with a 23-year history of SLE presented with renal function loss and nephrotic syndrome.
- Renal biopsy revealed AA amyloid deposition confirmed by Congo red staining and specific antibody reactivity.
- Histopathology showed immune deposits in the glomeruli but lacked features of lupus nephritis.
Findings:
- The renal biopsy confirmed AA amyloidosis in a patient with a long-standing history of SLE.
- Distinct pathological findings of lupus nephritis were absent despite the SLE diagnosis.
- This case highlights the potential for amyloidosis to manifest in SLE patients.
Implications:
- The study discusses the rare association between SLE and AA amyloidosis.
- It emphasizes the role of the acute phase reaction in SLE concerning amyloidosis development.
- Understanding this association is crucial for accurate diagnosis and management of complex cases.