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Updated: Jan 3, 2026

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Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
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Vanishing white matter disease imaged over 3 years
Denny Mathew1, Nasreen Mahomed1,2,3
1Department of Radiology, University of the Witwatersrand, South Africa.
SA Journal of Radiology
|November 23, 2019
Summary
Childhood ataxia and central nervous system hypomyelination (CACH), or vanishing white matter disease (VWM), is a progressive neurological disorder. Early MRI findings, particularly corpus callosum involvement, aid in diagnosing this rare condition.
Area of Science:
- Neurology
- Genetics
- Pediatrics
Background:
- Childhood ataxia and central nervous system hypomyelination (CACH), also known as vanishing white matter disease (VWM), is a rare autosomal recessive leukoencephalopathy.
- The disease typically presents with initial normal psychomotor development followed by chronic, progressive neurological deterioration, often triggered by stress factors.
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