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Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
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Poly hydroxyalkanoates (PHA): Role in bone scaffolds.

Ruby Dwivedi1, Rahul Pandey2, Sumit Kumar2

  • 1Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, KGMU, Lucknow, UP, India.

Journal of Oral Biology and Craniofacial Research
|November 23, 2019
PubMed
Summary
This summary is machine-generated.

Polyhydroxyalkanoates (PHA) offer excellent biocompatibility and mechanical properties for medical devices. This review highlights PHA

Keywords:
Bone tissue engineeringPolyhydroxyalkanoatesPolyhydroxybutyrateScaffolds

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Polyhydroxyalkanoates (PHA) are biopolyesters synthesized by microorganisms.
  • PHAs exhibit favorable properties like biocompatibility, biodegradability, and tunable mechanical characteristics.
  • Their versatility makes them promising for biomedical applications, particularly bone tissue engineering.

Purpose of the Study:

  • To review the production, characteristics, and applications of Polyhydroxyalkanoates (PHAs).
  • To emphasize the role of PHAs and their copolymers as scaffolds in bone tissue engineering.

Main Methods:

  • Literature review of PHA production, properties, and applications.
  • Analysis of PHA physico-chemical characteristics, mechanical properties, and degradation rates.
  • Focus on PHA utilization in bone tissue engineering scaffolds.

Main Results:

  • PHAs are produced from various microbial sources.
  • Key properties include biocompatibility, tunable mechanical strength, and controllable degradation.
  • PHAs demonstrate significant potential as scaffolds for bone regeneration.

Conclusions:

  • Polyhydroxyalkanoates are versatile biopolymers with significant potential in bone tissue engineering.
  • Further research into PHA copolymers can optimize scaffold performance for enhanced bone regeneration.