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Related Experiment Video

Updated: Jan 3, 2026

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Virus-Receptor Interactions: Structural Insights For Oncolytic Virus Development.

Nadishka Jayawardena¹, Laura N Burga¹, John T Poirier²

¹Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.

Oncolytic Virotherapy

|November 23, 2019

Summary

Oncolytic virus (OV) therapy is advancing, with modifications to viral proteins enhancing cancer cell targeting. Understanding virus-receptor interactions aids in developing OVs for improved tumor specificity and broader cancer treatment applications.

Keywords:

oncolytic viruses virus entry virus–receptor interaction

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Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus

Published on: May 13, 2021

Area of Science:

Oncology
Virology
Structural Biology

Background:

Oncolytic virotherapy utilizes viruses to selectively target and destroy cancer cells.
Modifying viral surface proteins is a key strategy for enhancing oncolytic virus (OV) efficacy and specificity.
Structural insights into virus-receptor interactions are crucial for understanding OV tropism.

Purpose of the Study:

To review strategies for developing novel oncolytic viruses (OVs) for cancer therapy.
To discuss the role of structural knowledge in understanding and engineering OV tumor targeting.
To explore repurposing OVs through modifications for improved cancer treatment.

Main Methods:

Review of current literature on oncolytic virotherapy.
Analysis of structural data on OV-receptor interactions.
Discussion of viral protein modification techniques for cancer targeting.

Main Results:

Detailed structural understanding of OV-natural receptor interactions informs tumor specificity.
Receptor re-targeting strategies can broaden tumor tropism or enhance selectivity.
Viral envelope and coat protein modifications are effective for repurposing OVs.

Conclusions:

Structural biology provides critical insights for advancing oncolytic virus therapy.
Engineering OVs through protein modification offers promising avenues for cancer treatment.
Targeted modifications can optimize OV tropism for enhanced anti-cancer efficacy.