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Related Concept Videos

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Related Experiment Video

Updated: Jan 3, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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ENCORE: A Visualization Tool for Insight into Circadian Omics.

Hannah De Los Santos1, Kristin P Bennett1, Jennifer M Hurley2

  • 1Institute for Data Exploration and Applications/Department of Computer Science, Rensselaer Polytechnic Institute, Troy, NY.

ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine
|November 23, 2019
PubMed
Summary

Scientists developed ENCORE, a new tool to explore circadian rhythms. It links oscillating genes to their functions, providing insights into cellular physiology across different organisms.

Keywords:
circadian rhythmsgene enrichmentgene expressionprotein-protein interaction networksproteomicstranscriptomicsvisualizations

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Area of Science:

  • * Chronobiology and Systems Biology
  • * Genomics and Molecular Biology

Background:

  • * Circadian rhythms govern daily molecular oscillations in organisms.
  • * Omics-scale data reveal circadian regulation's impact on cellular physiology.
  • * Previous tools like ECHO identified circadian oscillations but lacked functional context.

Purpose of the Study:

  • * To develop a novel tool, ENCORE, for functional analysis of circadian rhythms.
  • * To integrate Gene Ontologies, protein-protein interactions, and auxiliary data.
  • * To provide meaningful context for circadianly-regulated genes.

Main Methods:

  • * Development of ENCORE (ECHO Native Circadian Ontological Rhythmicity Explorer).
  • * Integration of multiple biological databases (Gene Ontology, PPIs).
  • * Application of ENCORE to omics data from mouse, fruit fly, and *Neurospora crassa*.

Main Results:

  • * ENCORE enables automatic enrichment analysis of circadian rhythm data.
  • * The tool generates publication-quality visualizations for circadian gene functions.
  • * Previously observed amplitude changes in circadian oscillations are functionally linked.

Conclusions:

  • * ENCORE provides functional insights into circadianly-regulated genes.
  • * The tool enhances understanding of circadian regulation of physiology.
  • * ENCORE is a valuable resource for chronobiology research across model organisms.