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The Relationship Between Homocysteine, Blood Pressure Variability, and Left Ventricular Hypertrophy in Patients with

Bei-You Lin1, Ping Li2, Xiao-Dan Wu1

  • 1Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University & Guangxi Key Laboratory Base of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention and Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, Nanning, 530021, China.

Advances in Therapy
|November 23, 2019
PubMed

Insights

Elevated homocysteine (Hcy) levels correlate with increased blood pressure variability (BPV) and left ventricular hypertrophy (LVH) in patients with essential hypertension. Monitoring Hcy is crucial for managing these conditions.

Area of Science:

  • Cardiology
  • Clinical Biochemistry

Background:

  • Essential hypertension is a significant risk factor for cardiovascular disease.
  • Blood pressure variability (BPV) and left ventricular hypertrophy (LVH) are indicators of cardiovascular risk.
  • Homocysteine (Hcy) is an amino acid linked to endothelial dysfunction and cardiovascular events.

Purpose of the Study:

  • To investigate the relationship between homocysteine (Hcy) levels and blood pressure variability (BPV).
  • To examine the association between Hcy and left ventricular hypertrophy (LVH) in patients with essential hypertension.

Main Methods:

  • 102 patients with essential hypertension were divided into two groups based on Hcy concentration (<10 μmol/L and ≥10 μmol/L).
  • BPV parameters (nocturnal diastolic blood pressure variation, nocturnal systolic blood pressure standard deviation) and LVH indicators (interventricular septal thickness, left ventricular posterior wall thickness) were measured.
  • Correlations between Hcy levels and BPV/LVH were analyzed.

Main Results:

  • Significant differences in BPV and LVH were observed between the Hcy groups.
  • Hcy showed a positive correlation with nocturnal diastolic blood pressure variation (r=0.331, P<0.001) and nocturnal systolic blood pressure standard deviation (r=0.303, P<0.001).
  • Hcy also positively correlated with interventricular septal thickness (r=0.350, P<0.001) and left ventricular posterior wall thickness (r=0.352, P<0.001).

Conclusions:

  • A significant correlation exists between homocysteine levels and both blood pressure variability and left ventricular hypertrophy in essential hypertension.
  • Monitoring blood homocysteine levels is recommended for patients with essential hypertension to assess cardiovascular risk.
Abstract

Keywords:
Blood pressure variabilityEssential hypertensionHomocysteineLeft ventricular hypertrophyRelationship

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