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A new lanostane triterpenoid from Ganoderma resinaceum
Qiaofen Yang1, Kejun He2, Shiyu Qiu2
1School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China.
Journal of Asian Natural Products Research
|November 23, 2019
Summary
Researchers isolated a novel nortriterpenoid, resinacein T, from Ganoderma resinaceum. This study details its structure and that of two known triterpenoids using advanced spectroscopic methods.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Medicinal Mycology
Background:
- Ganoderma species are known for producing bioactive triterpenoids.
- Traditional use of Ganoderma resinaceum suggests potential for novel compound discovery.
- The chemical diversity of Ganoderma-derived triterpenoids remains an active area of research.
Purpose of the Study:
- To isolate and characterize new triterpenoids from Ganoderma resinaceum.
- To elucidate the structures of isolated compounds using spectroscopic techniques.
- To contribute to the understanding of the chemical constituents of Ganoderma species.
Main Methods:
- Ethanol extraction of Ganoderma resinaceum fruiting bodies.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) analysis.
Main Results:
- A new five-nortriterpenoid, named resinacein T (1), was identified.
- Two known lanostane triterpenoids, 3β,7β,15α,24-tetrahydroxy-11,23-dioxo-lanost-8-en-26-oic acid (2) and resinacein O (3), were also isolated.
- The structures of all three compounds were successfully determined.
Conclusions:
- Resinacein T represents a novel structural class of nortriterpenoids.
- The findings expand the known repertoire of bioactive compounds from Ganoderma resinaceum.
- This study highlights the potential of Ganoderma species as a source for new natural products.
