Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Focused ultrasound thalamotomy for essential tremor in octogenarians.

Journal of neurosurgery·2026
Same author

Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies.

The journal of prevention of Alzheimer's disease·2026
Same author

The utility of the Whitaker test in the modern era of pediatric urology: A retrospective cohort study.

Journal of pediatric urology·2026
Same author

Selective brain cooling via cerebrospinal fluid exchange: Proof of concept in a porcine model.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Percutaneous Stereotactic Bedside Drainage and Active Fluid Exchange with Alteplase for Rapid Intracerebral Hemorrhage Evacuation: A Case Series.

Operative neurosurgery (Hagerstown, Md.)·2025
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Jan 3, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.7K

Deep Brain Stimulation for Multiple Sclerosis Tremor: A Meta-Analysis.

Nicholas J Brandmeir1,2, Ann Murray3,2, Cletus Cheyuo1,2

  • 1Department of Neurosurgery, West Virginia University, Morgantown, West Virginia.

Neuromodulation : Journal of the International Neuromodulation Society
|November 23, 2019
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) significantly improves tremor severity in multiple sclerosis (MS) patients. This meta-analysis of 13 studies provides evidence for DBS as a therapeutic option for MS-related tremor.

Keywords:
DBSMSdeep brain stimulationmultiple sclerosistremor

More Related Videos

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.0K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.2K

Related Experiment Videos

Last Updated: Jan 3, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.7K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.0K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.2K

Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Multiple sclerosis (MS) frequently causes disabling tremor.
  • Deep brain stimulation (DBS) is a potential therapeutic intervention for MS-tremor.

Purpose of the Study:

  • To systematically review and meta-analyze the efficacy of DBS in treating MS-tremor.
  • To assess the impact of DBS on tremor severity using standardized scales.

Main Methods:

  • A systematic literature search of Medline and EBSCO Host (1998-2018) was conducted.
  • Included studies reported outcomes using standardized tremor severity scales.
  • Risk of bias was assessed using American Academy of Neurology (AAN) standards.
  • Data were pooled using a random-effects meta-analysis with Hedges g normalization.

Main Results:

  • Thirteen studies were included in the meta-analysis.
  • DBS demonstrated a significant improvement in tremor severity, with a Hedges standardized mean difference of 2.86 (p < .00001).
  • High heterogeneity (I²=84%) indicated the appropriateness of the random-effects model. Adverse event rates ranged from 8% to 50%.

Conclusions:

  • This meta-analysis provides level III evidence supporting DBS for improving MS-related tremor.
  • DBS represents a viable treatment option for managing tremor in multiple sclerosis patients.