Related Experiment Video
Updated: Jan 3, 2026
10:57
Elaborate Control of Inkjet Printer for Fabrication of Chip-based Supercapacitors
Published on: November 30, 2021
3.1K
A Generalizable Single-Chip Calibration Method for Highly Quantitative SERS via Inkjet Dispense.
Fausto D'Apuzzo1, Raghuvir N Sengupta1, Milo Overbay1
1HP Inc. , 1501 Page Mill Road , Palo Alto , California 94340 , United States.
Analytical Chemistry
|November 23, 2019
Summary
Inkjet-dispense surface-enhanced Raman scattering (ID-SERS) enables highly accurate, quantitative measurements. This novel calibration method achieves low relative standard error for plasmonic sensing, paving the way for reproducible, automated applications.
Area of Science:
- Plasmonics
- Nanotechnology
- Analytical Chemistry
Background:
- Quantitative surface-enhanced Raman scattering (SERS) requires precise calibration.
- Existing methods can be time-consuming and require larger sample volumes.
- Reproducibility in SERS measurements remains a challenge for real-world applications.
Purpose of the Study:
- To develop a novel, high-resolution calibration method for quantitative SERS on a single chip.
- To demonstrate the accuracy and reproducibility of inkjet-dispense SERS (ID-SERS).
- To explore methods for enhancing the sensitivity and performance of ID-SERS.
Main Methods:
- Utilizing inkjet dispense technology to precisely pattern microdroplets for creating multiple standard curves on a single SERS substrate.
- Performing quantitative SERS measurements on aqueous solutions of 1,2-bis(4-pyridyl)ethylene (BPE).
- Investigating the impact of patterning density and sensor size on measurement accuracy.
- Employing layered inkjet dispense to enhance sensitivity.
Main Results:
- Achieved relative standard error (RSE) below 3% for quantitative SERS measurements, the lowest reported.
- Demonstrated that RSE scales with patterning density and sensor size, indicating potential for improved accuracy.
- Showcased advantages including speed (subsecond drop-and-dry), low sample volumes (<1 nL), and automation.
- Achieved a 30-fold enhancement in sensitivity using layered inkjet dispense.
Conclusions:
- ID-SERS offers a highly accurate and reproducible calibration method for quantitative plasmonic sensing.
- The technique is adaptable to various plasmonic substrates and offers significant advantages for practical applications.
- ID-SERS represents a significant advancement towards reliable quantitative sensing in real-world scenarios.
