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Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
Published on: January 5, 2016
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MicroRNAs and exosomes: key players in HIV pathogenesis
J Sadri Nahand1, F Bokharaei-Salim1, M Karimzadeh1
1Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
HIV Medicine
|November 23, 2019
Summary
MicroRNAs (miRNAs) and exosomes are key players in HIV pathogenesis, influencing viral replication and immune response. These molecules also show potential as diagnostic biomarkers for HIV infection.
Area of Science:
- Immunology
- Virology
- Molecular Biology
Background:
- HIV infection severely impairs the human immune system, primarily targeting T lymphocytes.
- The virus inactivates T lymphocytes by disrupting cellular and molecular pathways, leading to immune suppression.
Purpose of the Study:
- To review the extent of microRNA (miRNA) involvement in Human Immunodeficiency Virus (HIV) pathogenesis.
- To explore the role of exosomes in HIV pathogenesis.
Main Methods:
- A comprehensive literature search was conducted using PubMed and Google Scholar.
- The search covered scientific literature published between 1988 and 2019.
Main Results:
- Evidence indicates miRNAs modulate viral replication and immune responses by targeting viral transcripts and host pathways.
- Exosomes function as nanoscale carriers, transporting various molecules including miRNAs, and altering recipient cell behavior in HIV pathogenesis.
Conclusions:
- MicroRNAs and exosomes are significant contributors to HIV pathogenesis.
- miRNAs present potential as diagnostic biomarkers for HIV infection.
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