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Phenytoin monitoring: clinical or scientific?
J D Fulton1, E M McGovern, B N McCarron
1Department of Geriatric Medicine, Stobhill General Hospital, Glasgow.
Scottish Medical Journal
|June 1, 1988
Abstract:
Phenytoin is an established therapy for post-herpetic neuralgia. In order to maintain serum phenytoin levels in the normal therapeutic range, serum phenytoin monitoring is required. This range may, however, be misleading in certain clinical conditions. We report here a patient with hypoalbuminaemia who developed marked clinical phenytoin toxicity despite maintenance of the serum total phenytoin concentration within the therapeutic range.