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Updated: Jan 3, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Anti-M-Induced Delayed Hemolytic Transfusion Reaction
Emmanuel A Fadeyi1,2, Tawfeq Naal1,2, Mary Green1,2
1Department of Pathology & Laboratory Medicine, Wake Forest University School of Medicine.
In a patient with severe trauma, IgG anti-M antibodies were detected after a blood transfusion, necessitating the use of M antigen-negative red blood cells (RBCs) for successful treatment.
Area of Science:
- Transfusion Medicine
- Immunology
- Hematology
Background:
- Anti-M antibodies are typically naturally occurring IgM antibodies.
- These antibodies are usually not clinically significant as they do not react at 37°C.
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