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Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated

Lujie Fan1, Ying Peng1, Dan Wu1

  • 1Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Sciences and Technologies, Northwest A&F University, Yangling, Shaanxi, China.

Journal of Ethnopharmacology
|November 23, 2019
PubMed
Summary

Mulberry leaf supplementation in pigs reduced fat deposition by altering lipid metabolism and enhancing leptin signaling. This study supports mulberry leaves as a potential anti-obesity agent.

Keywords:
Anti-obese plantsLeptinLipolysisMulberry leafPigs

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Area of Science:

  • Nutritional Science
  • Metabolic Research
  • Pharmacology

Background:

  • Mulberry leaves (Morus nigra L.) have a history of medicinal use in China.
  • Traditional applications include anti-stress, blood glucose lowering, and anti-obesity effects.

Purpose of the Study:

  • To investigate the impact of mulberry leaves on fat deposition in pigs.
  • To elucidate the underlying molecular mechanisms of mulberry leaves' effects on fat metabolism.

Main Methods:

  • 48 pigs were fed a normal diet or a diet supplemented with 5% mulberry leaf powder.
  • Measurements included backfat thickness, serum lipids, hormones (ELISA), and leptin signaling (Western blot).

Main Results:

  • Mulberry leaf supplementation reduced serum triglyceride and cholesterol, increased HDL-c/LDL-c ratio, and decreased adipocyte size and backfat thickness.
  • Hormone-sensitive lipase (HSL) was upregulated, fatty acid synthase (FAS) downregulated, and circulating leptin and adiponectin levels increased.
  • Enhanced leptin signaling (increased Leptin-R and p-STAT3) was observed in the subcutaneous fat of supplemented pigs.

Conclusions:

  • Mulberry leaves demonstrate significant anti-obesity effects in pigs.
  • These findings provide a scientific basis for developing mulberry leaves as a therapeutic agent for obesity.