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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

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Published on: January 17, 2018

Pituitary Stalk Interruption Syndrome.

Chuanna Xu¹, Tiejun Wang, Yan Feng

¹The First Hospital of Jilin University, Changchun, China.

The Journal of Craniofacial Surgery

|November 24, 2019

Summary

This summary is machine-generated.

Pituitary stalk interruption syndrome (PSIS) is a congenital condition causing hormone deficiencies. This case highlights a 22-year-old female with PSIS, growth retardation, and absent puberty, despite early growth hormone therapy.

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Area of Science:

Pediatric Endocrinology
Congenital Disorders
Hormone Replacement Therapy

Background:

Pituitary stalk interruption syndrome (PSIS) is a rare congenital disorder.
It is characterized by isolated or multiple anterior pituitary hormone deficiencies.
Growth hormone deficiency is a common manifestation, impacting linear growth.

Observation:

A 22-year-old female presented with a 13-year history of growth retardation.
The patient received growth hormone replacement therapy during childhood.
Secondary sexual characteristics had not developed.

Findings:

Despite early intervention with growth hormone therapy, the patient exhibited persistent growth deficits.
The absence of secondary sexual characteristics suggests co-existing deficiencies in gonadotropins or other pituitary hormones.
This case underscores the complex endocrine sequelae of PSIS.

Implications:

Early diagnosis and comprehensive endocrine assessment are crucial for managing PSIS.
Long-term monitoring is necessary to address potential deficiencies beyond growth hormone.
Understanding PSIS pathophysiology can inform future therapeutic strategies for congenital hypopituitarism.