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Related Experiment Video

Updated: Jan 3, 2026

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
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Andrographolide, a Natural Antioxidant: An Update.

Eugenie Mussard1, Annabelle Cesaro1, Eric Lespessailles1,2,3

  • 1Laboratory I3MTO, EA 4708, Université d'Orléans, 45067 Orléans Cedex 2, France.

Antioxidants (Basel, Switzerland)
|November 24, 2019
PubMed
Summary
This summary is machine-generated.

Andrographolide from Andrographis paniculata exhibits antioxidant properties by influencing the Nrf2 signaling pathway. This review details its antioxidant mechanisms for potential lung infection treatments.

Keywords:
Andrographis paniculataNrf2andrographolideoxidative stress

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Area of Science:

  • Pharmacology
  • Molecular Biology
  • Herbal Medicine

Background:

  • Andrographis paniculata is a traditional herbal remedy for lung infections.
  • Its active compound, andrographolide, possesses antioxidant, anti-inflammatory, and anti-cancer activities.

Purpose of the Study:

  • To review the antioxidant mechanisms of andrographolide.
  • To explore andrographolide's regulation of the Nrf2 signaling pathway.

Main Methods:

  • Literature review of studies on andrographolide's antioxidant effects.
  • Analysis of research on the Nrf2 signaling pathway and its modulation by andrographolide.

Main Results:

  • Andrographolide demonstrates significant antioxidant properties.
  • It effectively regulates the Nrf2 signaling pathway, a key cellular defense mechanism against oxidative stress.

Conclusions:

  • Andrographolide's antioxidant activity is mediated through the Nrf2 pathway.
  • This compound holds potential for therapeutic applications in conditions involving oxidative stress and inflammation, including lung infections.