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Precision Medicine in Pediatric Oncology
Kieuhoa T Vo1, D Williams Parsons2, Nita L Seibel3
1Department of Pediatrics, University of California San Francisco School of Medicine, Benioff Children's Hospital, 550 16th Street, 4th Floor, Box 0434, San Francisco, CA 94158, USA.
Surgical Oncology Clinics of North America
|November 24, 2019
Summary
Precision medicine improves pediatric cancer outcomes, but challenges persist for metastatic or recurrent cancers. This approach uses tumor molecular profiling for targeted therapies in children and adolescents.
Area of Science:
- Pediatric Oncology
- Cancer Genomics
- Precision Medicine
Background:
- Significant progress has been made in improving outcomes for pediatric cancer patients.
- However, challenges remain, especially for children with metastatic disease or cancers resistant to standard treatments.
Purpose of the Study:
- To describe the application of precision medicine in pediatric oncology.
- To highlight the unique challenges associated with implementing precision medicine in this population.
Main Methods:
- Review of current precision medicine trials in pediatric oncology.
- Analysis of individualized tumor molecular profiling for targeted therapy selection.
Main Results:
- Precision medicine approaches, similar to those in adult malignancies, are being adapted for pediatric cancers.
- Ongoing trials are exploring the efficacy of targeted therapies based on tumor molecular profiles.
Conclusions:
- Precision medicine holds promise for advancing pediatric cancer care.
- Addressing the specific challenges in pediatric oncology is crucial for successful implementation and improved patient outcomes.
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