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Silica nanocarriers with user-defined precise diameters by controlled template self-assembly.

Tânia Ribeiro1, Ana Sofia Rodrigues1, Sebastian Calderon2

  • 1Centro de Química-Física Molecular and Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.

Journal of Colloid and Interface Science
|November 24, 2019
PubMed
Summary

Researchers developed a sustainable, low-temperature method to create tunable mesoporous silica nanoparticles (MSNs). This aqueous sol-gel process allows precise control over MSN diameter for advanced nanocarrier applications.

Keywords:
CTAB micellesFluorescent labelMSNsMesoporous silica nanoparticlesMicelle stabilizationParticle size tuningPore morphology changeSupramicellar assembly

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemistry

Background:

  • Mesoporous silica nanoparticles (MSNs) are versatile nanocarriers due to their structure and surface chemistry.
  • A key challenge is controlling MSN diameter with narrow size distribution using scalable and sustainable methods.

Purpose of the Study:

  • To present a controllable, low-temperature, aqueous sol-gel method for synthesizing MSNs.
  • To achieve user-defined diameters ranging from 15 nm to 80 nm with narrow size dispersity.

Main Methods:

  • Utilized cetyltrimethylammonium bromide (CTAB) cylindrical micelles as a template.
  • Employed a sodium hydroxide (NaOH) catalyst and adjusted pH or salt concentration to control micelle colloidal stability.
  • Modified pore structure and incorporated luminescent species for optical traceability.

Main Results:

  • Successfully prepared MSNs with tunable diameters between 15 nm and 80 nm.
  • Achieved narrow size dispersity through precise control of micelle assembly.
  • Demonstrated the ability to alter pore structure and incorporate luminescent tags.

Conclusions:

  • The developed aqueous sol-gel method offers full control over MSN diameter and size dispersity.
  • This sustainable synthesis provides a platform for diverse applications requiring MSNs with specific sizes.
  • The method's adaptability allows for tailored MSN properties for advanced nanocarrier functions.