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In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
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Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior.

Lan Tang1, Michael J Higley1

  • 1Department of Neuroscience, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.

Neuron
|November 24, 2019
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Summary
This summary is machine-generated.

Pyramidal neurons (PNs) in the visual cortex form distinct networks. Layer 5 corticopontine neurons are crucial for visual detection and task performance, supporting adaptive behavior.

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Computational Neuroscience

Background:

  • Neocortical sensory areas function as distribution hubs for external environmental information.
  • Pyramidal neurons (PNs) in the primary visual cortex project to diverse downstream targets, implying independent cellular networks during behavior.

Purpose of the Study:

  • To investigate if specific PN subpopulations differentially support visual detection.
  • To explore the role of distinct PN networks in adaptive behavior.

Main Methods:

  • Mice were trained on a novel eyeblink conditioning task.
  • Two-photon calcium imaging and optogenetic manipulation were used to target anatomically defined PNs.

Main Results:

  • Layer 5 corticopontine neurons were found to strongly encode both sensory and motor task information.
  • Selective optogenetic manipulation demonstrated that these neurons are necessary for task performance.

Conclusions:

  • Target-specific cortical subnetworks are fundamental for adaptive behavior by directing information to distinct brain areas.
  • Neurons can form functionally segregated networks for parallel, independent control of perception and behavior.