Recurrent spontaneous coronary artery dissection in the United States
Chayakrit Krittanawong1, Anirudh Kumar2, Hafeez Ul Hassan Virk3
1Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America.
Insights
Recurrent spontaneous coronary artery dissection (SCAD) is more common than previously thought, affecting over a quarter of patients within a year. Female sex is a key predictor of recurrent SCAD.
Area of Science:
- Cardiology
- Vascular Medicine
- Epidemiology
Background:
- Spontaneous coronary artery dissection (SCAD) recurrence was considered infrequent.
- Predictors for SCAD recurrence remain poorly understood.
Purpose of the Study:
- To determine the incidence and clinical characteristics of recurrent SCAD.
- To identify independent predictors of SCAD recurrence.
Main Methods:
- Analysis of the Nationwide Readmissions Database (2010-2016).
- Inclusion of 1836 patients with a primary SCAD diagnosis.
- Multivariable analysis to identify predictors of recurrence within one year.
Main Results:
- The incidence of recurrent SCAD within one year was 26.9% among the study cohort.
- Female sex (OR 2.09) was identified as an independent predictor of recurrent SCAD.
- Recurrent SCAD was more prevalent in females (74.0%) and those under 65 (74%).
Conclusions:
- Recurrent SCAD is a frequent event, particularly in younger females with a history of SCAD.
- Female sex is a significant risk factor for SCAD recurrence.
- Further research is warranted to explore the underlying mechanisms linking female sex to SCAD recurrence.
Background:
Recurrent spontaneous coronary artery dissection (SCAD) is believed to be infrequent. Predictors of recurrent SCAD are poorly characterized.
Methods:
We evaluated the incidence, clinical characteristics, and predictors of recurrent SCAD using data from the Nationwide Readmissions Database from January 1, 2010, to December 30, 2016.
Results:
Among 1836 SCAD patients admitted with the primary diagnosis of SCAD (61.9% female, mean age 56.1 ± 14.5, 72.9% <65 years of age), 495 patients (26.9%) had recurrent SCAD within 1 year (74.0% female, 74% <65 years of age). Multivariable analysis showed that female sex (OR 2.09; 95% CI 1.49-2.95; p < 0.001) was an independent predictor of recurrent SCAD within 1 year.
Conclusions:
Recurrent SCAD is frequent and should be considered in younger females with a history of SCAD. Further research is needed to investigate the mechanistic links between female sex and recurrent SCAD.
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