Recurrent spontaneous coronary artery dissection in the United States

Chayakrit Krittanawong1, Anirudh Kumar2, Hafeez Ul Hassan Virk3

  • 1Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America.

Insights

Recurrent spontaneous coronary artery dissection (SCAD) is more common than previously thought, affecting over a quarter of patients within a year. Female sex is a key predictor of recurrent SCAD.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Epidemiology

Background:

  • Spontaneous coronary artery dissection (SCAD) recurrence was considered infrequent.
  • Predictors for SCAD recurrence remain poorly understood.

Purpose of the Study:

  • To determine the incidence and clinical characteristics of recurrent SCAD.
  • To identify independent predictors of SCAD recurrence.

Main Methods:

  • Analysis of the Nationwide Readmissions Database (2010-2016).
  • Inclusion of 1836 patients with a primary SCAD diagnosis.
  • Multivariable analysis to identify predictors of recurrence within one year.

Main Results:

  • The incidence of recurrent SCAD within one year was 26.9% among the study cohort.
  • Female sex (OR 2.09) was identified as an independent predictor of recurrent SCAD.
  • Recurrent SCAD was more prevalent in females (74.0%) and those under 65 (74%).

Conclusions:

  • Recurrent SCAD is a frequent event, particularly in younger females with a history of SCAD.
  • Female sex is a significant risk factor for SCAD recurrence.
  • Further research is warranted to explore the underlying mechanisms linking female sex to SCAD recurrence.
Abstract

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