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Updated: Jan 3, 2026
An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy
Published on: January 25, 2019
Surgical outcomes of vitrectomy surgery for proliferative diabetic retinopathy in patients with abnormal renal
P Larrañaga-Fragoso1, H Laviers2, C McKechnie3
1The Eye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Foundation Trust, London, E11 1NR, UK. paulalarranaga@gmail.com.
Purpose:
To analyse the influence of renal function on the outcomes of vitrectomy for tractional-related complications in cases of severe proliferative diabetic retinopathy (PDR).
Methods:
Retrospective consecutive case series of 109 eyes that underwent vitreoretinal interventions for traction-related complications of severe PDR from 2014 to 2017. Data collected included patient demographics, best-corrected visual acuity (BCVA), surgical complications, and systemic markers including HbA1c and estimated glomerular filtration rate (eGFR). Renal function categories were defined as low (eGFR < 30 mL/min/1.73 m2), medium (eGFR 30-60 mL/min/1.73 m2), and normal (eGFR > 60 mL/min/1.73m 2).
Results:
A total of 109 eyes (56% (n = 61) female) were included in the study. Overall, mean baseline BCVA improved from 1.33 logMAR to 0.91 logMAR (p < 0.001) postoperatively. Patients with low eGFR had significantly worse baseline BCVA (p = 0.039) and demonstrated greater improvement in mean BCVA (p = 0.059). Multivariate regression analysis indicated that seven predictors explained 65.5% of the variance (R2 = 0.655, F(11,97) = 16.7, p < 0.01).
Conclusions:
Reduced renal function does not adversely affect visual outcomes of vitrectomy for traction-related complications of PDR.
