Effects of vitamin D deficiency on intraocular pressure values obtained by ocular response analyzer

To compare corneal biomechanical properties measured with ocular response analyzer (ORA) and intraocular pressure (IOP) measurements in patients with vitamin D deficiency and in healthy cases.

One hundred and twenty eyes of 120 subjects (between the ages of 19 and 78) who applied to university's outpatient clinic were evaluated: 41 lacks of vitamin D (Group 1), 39 insufficient vitamin D (Group 2) and 40 controls (Group 3). Corneal hysteresis, corneal resistance factor, Goldmann-correlated IOP and corneal compensated IOP of patients were measured by ORA.

The mean ages were 48.9 ± 12.1, 52.8 ± 13.6 and 52.1 ± 13.9 in groups 1, 2 and 3, respectively (p = 0.370). Mean IOPcc values were 16.5 ± 3.6 (8.1-27.3), 16.7 ± 2.7 (12.0-22.7) and 16.3 ± 3.3 (10.8-27.4) mmHg (p = 0.889); mean IOPg values were 16.8 ± 5.0 (6.5-39.5), 16.3 ± 2.9 (10.3-23.0) and 15.9 ± 3.2 (10.0-26.0) mmHg (p = 0.539); mean CH values were 10.8 ± 1.9 (8.3-19.0), 11.4 ± 1.6 (6.9-14.0) and 11.2 ± 1.5 (7.5-13.2) (p = 0.257); mean CRF values were 10.5 ± 2.7 (7.4-25.0), 11.1 ± 1.5 (6.8-13.5) and 10.5 ± 1.2 (7.7-12.8) (p = 0.282) in groups 1, 2 and 3, respectively. There was no statistical difference between the groups in terms of IOPcc, IOPg CH and CRF. However, mean CH values were found less in the lack of vitamin D group.

The CH values were lower, and the IOPg values were higher in cases of vitamin D deficiency. Corneal biomechanical differences in patients with lack of vitamin D were not statistically significant.