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Chronic myeloid leukemia-derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic

Julian Swatler1, Wioleta Dudka1, Lukasz Bugajski1

  • 1Laboratory of Cytometry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

European Journal of Immunology
|November 24, 2019
PubMed

Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression of Foxp3 transcription factor. This could facilitate expansion of leukemic cells outside the bone marrow, leading to blast crisis.

Keywords:
Foxp3chronic myeloid leukemiaextracellular vesiclesimmunosuppressionregulatory T cells

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