Related Experiment Video
Updated: Jan 3, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
[Pyomyositis due to Streptococcus pyogenes in a patient with venolymphatic malformation. Report of one pediatric
Ernestina Sarmiento1, María E Padilla2, Antonela Oyarbide1
1Residencia de Clínica Pediátrica, Hospital de Niños "Dr. Ricardo Gutiérrez", Ciudad Autónoma de Buenos Aires, Argentina.
Insights
Streptococcus pyogenes can cause invasive pyomyositis in children, even in those with underlying conditions like vascular malformations. This case highlights a rare presentation of a serious pediatric infection.
Area of Science:
- Pediatric infectious diseases
- Vascular malformations
- Microbiology
Background:
- Streptococcus pyogenes is a common pediatric pathogen causing pharyngitis and skin infections.
- Invasive Streptococcus pyogenes infections, including pyomyositis, are less frequent but carry significant morbidity and mortality (7% in children).
- Vascular malformations can predispose individuals to infections, though their association with pyomyositis is not well-documented.
Observation:
- An 11-year-old patient with a subscapular venolymphatic malformation presented with fever and localized pain.
- The lesion associated with the malformation acutely increased in size.
- Clinical presentation suggested an infectious process superimposed on the malformation.
Findings:
- Diagnostic workup confirmed pyomyositis, an infection of the muscle, as the cause of the patient's symptoms.
- Streptococcus pyogenes was identified as the causative agent.
- The infection was localized to the area of the venolymphatic malformation.
Implications:
- This case underscores the importance of considering invasive bacterial infections in pediatric patients with vascular malformations presenting with acute symptoms.
- Early diagnosis and treatment of Streptococcus pyogenes pyomyositis are crucial to prevent severe complications and reduce mortality.
- Further research may explore the specific mechanisms by which vascular malformations might increase susceptibility to invasive infections like pyomyositis.
Abstract:
Streptococcus pyogenes infections are common in the pediatric population in the form of tonsillopharyngitis or cutaneous disease. Less frequently, it presents with invasive forms such as pyomyositis or necrotizing fasciitis. Mortality in children is of 7 %. We present an 11-year-old patient with a subscapular venolymphatic malformation who consulted for febrile syndrome associated with pain and an acute increase in the size of the lesion. During the hospitalization, diagnosis of pyomyositis due to Streptococcus pyogenes was reached.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Pyelonephritis I: Introduction
Pleural Effusion I: Introduction
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
Mitral Stenosis III: Medical Management
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

