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Updated: Jan 3, 2026
Author Spotlight: Enhanced Method for Evaluating Analgesic Effects — Dual Hind Paw Carrageenan Injection in Mice
Published on: November 15, 2024
Analgesic effect and related amino acids regulation of ginsenoside Rg3 in mouse pain models
Yu-Qi Sun1, Shu-Dan Shi1, Yan Zheng1
1School of Pharmacy, Jinzhou Medical University, Jinzhou, PR China.
Aims:
The present study aims to evaluate the analgesic effect of ginsenoside Rg3 in different mouse pain models.
Main Methods:
Formalin-, carrageenan- and S180 tumor cells induced mouse pain models were built in the study. The licking and biting time and PEG2 contents in the inflammatory sites were measured. The excitatory and inhibitory amino acids in the brains were determined by pre-column derivation FLD-HPLC method.
Key Finding:
We have found that ginsenoside Rg3 treated the pain phases and decreased the PGE2 in formalin and carrageenan induced models, respectively. It significantly increased the contents of EAAs (Asp and Glu) in the brains of S180 tumor inducing pain mice, meanwhile, the IAAs (Gly, Tau and GABA) decreased.
Significance:
Our results revealed that ginsenoside Rg3 acted central and peripheral analgesic effect and regulated the inflammatory factors and pain-related amino acids. It could re-balance the abnormal EAAs/IAAs value when the pain occurred. The analgesic mechanism and the clinical application of ginsenoside Rg3 need be evaluated furtherly.
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