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Related Experiment Videos

[Plasmapheresis in clinical practice].

Iu E Malakhovskiĭ, F K Manerov, T A Gicheva

    Terapevticheskii Arkhiv
    |January 1, 1988
    PubMed
    Summary

    Intermittent plasmapheresis improved outcomes in severe pediatric inflammatory and immune diseases. This therapy can be a primary treatment for conditions like viral hepatitis and vasculitis.

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    Area of Science:

    • Pediatric Medicine
    • Immunology
    • Critical Care

    Context:

    • Severe bacterial-inflammatory and immune-mediated diseases in children often present with high morbidity and mortality.
    • Refractory cases pose significant therapeutic challenges, necessitating advanced treatment modalities.

    Purpose:

    • To evaluate the efficacy and safety of intermittent plasmapheresis in pediatric patients with severe, refractory diseases.
    • To explore plasmapheresis as an adjunctive or independent therapeutic option.

    Summary:

    • Intermittent plasmapheresis was applied to 220 children suffering from severe bacterial-inflammatory and immune-mediated conditions.
    • When used with standard therapies, plasmapheresis enhanced treatment effectiveness.
    • For specific conditions like viral hepatitis with liver failure, bullous erythema, and hemorrhagic vasculitis, plasmapheresis demonstrated utility as a standalone treatment.

    Impact:

    • Differentiated therapeutic protocols for plasmapheresis were developed and implemented.
    • The study confirmed the safety profile of intermittent plasmapheresis in this pediatric cohort.
    • Improved clinical outcomes were observed in patients receiving plasmapheresis, highlighting its value in managing complex pediatric diseases.

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