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Soluble epoxide hydrolase in the human placenta throughout gestation
Tai-Ho Hung1, Szu-Fu Chen2, T'sang-T'ang Hsieh3
1Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Taiwanese Journal of Obstetrics & Gynecology
|November 25, 2019
Summary
Soluble epoxide hydrolase (sEH) levels increase in the human placenta during gestation. Hypoxia-reoxygenation (HR) significantly elevates sEH expression, suggesting its role in placental development and response to oxygen stress.
Area of Science:
- Reproductive biology
- Biochemistry
- Human physiology
Background:
- Soluble epoxide hydrolase (sEH) is an enzyme implicated in various physiological processes.
- Understanding sEH dynamics in the human placenta is crucial for comprehending pregnancy development and potential complications.
Purpose of the Study:
- To map the spatial and temporal expression patterns of sEH in the human placenta across gestation.
- To investigate the impact of hypoxia-reoxygenation (HR) on sEH expression in placental villous explants in vitro.
Main Methods:
- Human placental samples were collected at early, mid, and late gestation.
- Immunohistochemistry, Western blot, and qPCR were employed to analyze sEH localization and quantity.
- Villous explant cultures were subjected to controlled hypoxia-reoxygenation cycles.
Main Results:
- sEH immunoreactivity was primarily detected in cytotrophoblasts and syncytiotrophoblasts throughout gestation.
- sEH mRNA and protein levels significantly increased from early to mid and late gestation.
- HR exposure led to a significant upregulation of sEH mRNA and protein in placental explants.
Conclusions:
- sEH likely plays a critical role in human placental development.
- Hypoxia-reoxygenation emerges as a potential regulator of sEH expression within the placenta.
