Paclitaxel-related dermatological problems: Not only alopecia occurs

Area of Science:

• Oncology
• Dermatology
• Gynecology

Background:

• Dermatological side effects of chemotherapy are often overlooked in gynecological oncology.
• Paclitaxel is a widely used chemotherapy agent for gynecological cancers, yet its specific dermatologic effects are infrequently documented.

Observation:

• Two patients with gynecological malignancies developed skin problems, including dermatitis, eczema, and folliculitis, on the scalp, face, and upper trunk.
• These symptoms occurred during a postoperative treatment regimen of weekly paclitaxel (80 mg/m²) and carboplatin.

Findings:

• The observed dermatologic conditions responded effectively to topical antifungal creams and oral antihistamines.
• These interventions halted disease progression, enabling both patients to complete their chemotherapy cycles without dose modification or interruption.

Implications:

• Healthcare providers should recognize and monitor for paclitaxel-induced skin toxicities, particularly on the head, face, and upper torso.
• Awareness and prompt management of these dermatologic issues are crucial for reducing patient morbidity and enhancing quality of life during cancer treatment, especially when cure is the primary goal.