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Streptococcus pseudopneumoniae, an opportunistic pathogen in patients with cystic fibrosis

Chloé Dupont1, Anne-Laure Michon2, Marion Normandin3

  • 1HydroSciences Montpellier, Université de Montpellier, CNRS, IRD, Laboratoire d'Ecologie Microbienne Hospitalière, Montpellier University Hospital, France.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|November 25, 2019
PubMed

Insights

Streptococcus pseudopneumoniae is a newly identified opportunistic pathogen in cystic fibrosis (CF) patients. This bacterium is linked to pulmonary exacerbations, necessitating further research into its role in CF lung disease.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Streptococcus pseudopneumoniae is a known pathogen in chronic respiratory diseases.
  • Its presence and role in cystic fibrosis (CF) patients have not been previously characterized.
  • Accurate identification is challenging due to similarity with other Streptococcus mitis group species.

Purpose of the Study:

  • To investigate the presence and clinical significance of Streptococcus pseudopneumoniae in CF patients.
  • To confirm the identification of S. pseudopneumoniae isolates from CF patient samples.
  • To assess the association of S. pseudopneumoniae with pulmonary exacerbations in CF.

Main Methods:

  • Inclusion of twenty CF patients with S. pseudopneumoniae isolates.
  • Initial identification using routine phenotypic methods.
  • Confirmation via recA sequencing and species-specific marker amplification.
  • Review of microbiological and clinical data.

Main Results:

  • Thirteen of the initial isolates were confirmed as Streptococcus pseudopneumoniae.
  • S. pseudopneumoniae was found in 46% of patients, often contributing to pulmonary exacerbations.
  • It was identified as either the sole pathogen or part of a polymicrobial infection.

Conclusions:

  • Streptococcus pseudopneumoniae should be considered an opportunistic pathogen in CF patients.
  • Further studies are required to understand its epidemiology and clinical impact in CF.
  • Improved diagnostic methods may be needed for accurate identification.
Keywords:
Cystic fibrosisExacerbationIdentificationOpportunistic pathogenResistanceStreptococcus pseudopneumoniae

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