Bladder overactivity and post-void residual: Which relates more to systemic atherosclerotic markers?

Area of Science:

• Urology
• Cardiology
• Geriatrics

Background:

• Lower urinary tract dysfunction (LUTD) and atherosclerosis share known associations.
• The specific LUTD type correlating with atherosclerosis remains unclear.
• This study investigates detrusor overactivity versus post-void residual in relation to atherosclerosis.

Purpose of the Study:

• To determine which LUTD subtype, detrusor overactivity or post-void residual, is more closely associated with atherosclerosis.
• To explore the relationship between urodynamic findings and systemic vascular health.

Main Methods:

• Standard urodynamic testing was performed on 183 patients (age > 60).
• Atherosclerosis was assessed using cardio-ankle vascular stiffness index (CAVI) and duplex carotid ultrasonography.
• Patients included 109 men and 74 women, with mean ages around 66.4 years.

Main Results:

• Detrusor overactivity showed a significant positive correlation with high CAVI values (p < 0.05).
• No significant association was found between detrusor overactivity and carotid intima-media thickness.
• Post-void residuals did not demonstrate a significant relationship with either CAVI or carotid intima-media thickness.

Conclusions:

• Urodynamic detrusor overactivity, potentially indicating central etiology, is positively linked to systemic atherosclerosis (measured by CAVI).
• Post-void residuals, possibly reflecting peripheral etiology, did not show a similar association with systemic atherosclerosis.
• Findings suggest detrusor overactivity may serve as a marker for systemic vascular disease in older adults.