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Published on: June 23, 2020
A near-infrared fluorescent probe based on boric acid hydrolysis for hydrogen peroxide detection and imaging in HeLa
Tao Wang1,2, Xiaojun Yang1,2, Jinxia Men3
1Center of Drug Discovery, State Key Laboratory of Natural Medicines, Pharmaceutical University, Nanjing, China.
Abstract:
Using the characteristics of hydrogen peroxide that are able to cleave phenyl-boric acid selectively and efficiently, we here report a dicyanoisophorone-boric acid (DCP-BA)-based near-infrared (NIR) fluorescent probe for detection of hydrogen peroxide. This probe shows a rapid, highly selective, and sensitive detection process for hydrogen peroxide with a significant NIR fluorescent turn-on response that has been successfully applied to detect exogenous hydrogen peroxide in HeLa cells.

